by Skilling | Feb 17, 2023 | Immune |
Nitric oxide (NO) is a free radical synthesized from L-arginine by three different NO-synthases (NOS). NO exhibits multiple and complex biological functions and many of its effects can be mostly attributed to its strong oxidant capacity, which provides it a high...
by Skilling | Feb 17, 2023 | Immune |
Nitric oxide (NO) is a free radical synthesized from L-arginine by different isoforms NO-syntheses. NO possesses multiple and complex biological functions. NO is an important mediator of homeostasis, and changes in its generation or actions can contribute or not to...
by Skilling | Feb 17, 2023 | Immune |
Nitric Oxide (NO), a lipophilic gas synthesized by the enzyme Nitric Oxide Synthase (NOS) from the substrate arginine, is an important biomolecule that mediates cellular signaling. It has a wide spectrum of biological functions including immunomodulation,...
by Skilling | Feb 17, 2023 | Cardiovascular |
Nitric oxide (NO) is a key molecule in cardiovascular homeostasis and its abnormal delivery is highly associated with the occurrence and development of cardiovascular disease (CVD). The assessment and manipulation of NO delivery is crucial to the diagnosis and therapy...
by Skilling | Feb 17, 2023 | Cardiovascular |
Nitric oxide (NO) is a ubiquitous, naturally occurring molecule found in a variety of cell types and organ systems. In the cardiovascular system, NO is an important determinant of basal vascular tone, prevents platelet activation, limits leukocyte adhesion to the...
by Skilling | Feb 17, 2023 | Cardiovascular |
Dysfunction of the normally protective endothelium is found in several cardiovascular diseases, including atherosclerosis, hypertension, heart failure, coronary heart disease, arterial thrombotic disorders, and stroke. Endothelial dysfunction leads to nitric oxide...
by Skilling | Feb 17, 2023 | Cardiovascular |
Aside from its importance for blood flow and blood pressure via endothelium-dependent vasodilation, endothelial NO synthase (eNOS) has been shown to have numerous other vascular protective effects including, but not limited to, inhibition of platelet aggregation and...
by Skilling | Feb 17, 2023 | Cardiovascular |
Nitric oxide (NO) is a recently appreciated regulator molecule for leukocytes, endothelial cells of blood vessels, and neurons in the brain and peripheral nervous system. NO is handled in the body quite differently from other autacoids and neurotransmitters such as...
by Skilling | Feb 17, 2023 | Cardiovascular |
Inducible nitric oxide synthase (iNOS) activity increases in acute and chronic inflammatory lung diseases. Imaging iNOS expression may be useful as an inflammation biomarker for monitoring lung disease activity. We developed a novel tracer for PET that binds to iNOS...
by Skilling | Feb 17, 2023 | Digestive |
The disruption of gut microbiota homeostasis has been associated with numerous diseases and with a disproportionate inflammatory response, including overproduction of nitric oxide (NO) in the intestinal lumen. However, the influence of NO on the human gut microbiota...
