Dietary NO Precursors and Exercise Performance

NO has received significant attention in exercise physiology and sports nutrition, with many NO “supplements” being sold as potential ergogenic aids. This is based on the important role of NO in many physiological processes related to exercise and recovery, including...

NO and Inflammatory Joint Diseases

After induction by certain cytokines or endotoxin, this latter isoform produces large quantities of NO with cyto- and bacteriotoxic effects. High amounts of NO, synthesized systemically and intra-articularly, play an important role in inflammatory joint diseases, as...

NO in Inflammation and Pain Associated with OA

Osteoarthritis (OA) is a degenerative disease involving chondrocytes, cartilage and other joint tissues, and has a number of underlying causes, including both biochemical and mechanical factors. Although proinflammatory factors including nitric oxide (NO) are...

NO Role in Pathogenesis of RA and Lupus

Nitric oxide (NO) has been shown to regulate T cellfunctions under physiological conditions, but overproduction of NO may contribute to T lymphocyte dysfunction. NO-dependent tissue injury has been implicated in a variety of rheumatic diseases, including systemic...

NO for Treating Rheumatoid Arthritis

Di-tert-butyl dicarbonate, 4-nitro-O-phenylenediamine, guanidine hydrochloride, sodium sulfate, palladium on carbon (PD/C), tetrahydrofuran, Celite® 545 AW, acryloyl chloride, trimethylamine, TFA, pyrrolidine, acetonitrile, sodium methoxide, N,N’-dimethylformamide,...

Reemergence of NO and Cancer

Nitric Oxide (NO), a lipophilic gas synthesise Ad by the enzyme Nitric Oxide Synthase (NOS) from the substrate arginine, is an important biomolecule that mediates cellular signaling. It has a wide spectrum of biological functions including immunomodulation,...

NO and the Immune Response

During the past two decades, nitric oxide (NO) has been recognized as one of the most versatile players in the immune system. It is involved in the pathogenesis and control of infectious diseases, tumors, autoimmune processes and chronic degenerative diseases. Read...