by Skilling | Feb 17, 2023 | Cardiovascular |
Nitric oxide (NO) is a key molecule in cardiovascular homeostasis and its abnormal delivery is highly associated with the occurrence and development of cardiovascular disease (CVD). The assessment and manipulation of NO delivery is crucial to the diagnosis and therapy...
by Skilling | Feb 17, 2023 | Cardiovascular |
Nitric oxide (NO) is a ubiquitous, naturally occurring molecule found in a variety of cell types and organ systems. In the cardiovascular system, NO is an important determinant of basal vascular tone, prevents platelet activation, limits leukocyte adhesion to the...
by Skilling | Feb 17, 2023 | Cardiovascular |
Dysfunction of the normally protective endothelium is found in several cardiovascular diseases, including atherosclerosis, hypertension, heart failure, coronary heart disease, arterial thrombotic disorders, and stroke. Endothelial dysfunction leads to nitric oxide...
by Skilling | Feb 17, 2023 | Cardiovascular |
Aside from its importance for blood flow and blood pressure via endothelium-dependent vasodilation, endothelial NO synthase (eNOS) has been shown to have numerous other vascular protective effects including, but not limited to, inhibition of platelet aggregation and...
by Skilling | Feb 17, 2023 | Cardiovascular |
Nitric oxide (NO) is a recently appreciated regulator molecule for leukocytes, endothelial cells of blood vessels, and neurons in the brain and peripheral nervous system. NO is handled in the body quite differently from other autacoids and neurotransmitters such as...
by Skilling | Feb 17, 2023 | Cardiovascular |
Inducible nitric oxide synthase (iNOS) activity increases in acute and chronic inflammatory lung diseases. Imaging iNOS expression may be useful as an inflammation biomarker for monitoring lung disease activity. We developed a novel tracer for PET that binds to iNOS...
