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NO and Inflammatory Joint Diseases
After induction by certain cytokines or endotoxin, this latter isoform produces large quantities of NO with cyto- and bacteriotoxic effects. High amounts of NO, synthesized systemically and intra-articularly, play an important role in inflammatory joint diseases, as...
NO Mediator of Apoptosis in Rheumatoid Joints
Objective: To study the role of nitric oxide (NO) derived from the inducicle nitric oxide synthase (iNOS) pathway n the induction of apoptosis in the rheumatoid joint. Read More
NO in Inflammation and Pain Associated with OA
Osteoarthritis (OA) is a degenerative disease involving chondrocytes, cartilage and other joint tissues, and has a number of underlying causes, including both biochemical and mechanical factors. Although proinflammatory factors including nitric oxide (NO) are...
NO Role in Pathogenesis of RA and Lupus
Nitric oxide (NO) has been shown to regulate T cellfunctions under physiological conditions, but overproduction of NO may contribute to T lymphocyte dysfunction. NO-dependent tissue injury has been implicated in a variety of rheumatic diseases, including systemic...
NO for Treating Rheumatoid Arthritis
Di-tert-butyl dicarbonate, 4-nitro-O-phenylenediamine, guanidine hydrochloride, sodium sulfate, palladium on carbon (PD/C), tetrahydrofuran, Celite® 545 AW, acryloyl chloride, trimethylamine, TFA, pyrrolidine, acetonitrile, sodium methoxide, N,N’-dimethylformamide,...
Reemergence of NO and Cancer
Nitric Oxide (NO), a lipophilic gas synthesise Ad by the enzyme Nitric Oxide Synthase (NOS) from the substrate arginine, is an important biomolecule that mediates cellular signaling. It has a wide spectrum of biological functions including immunomodulation,...
NO and the Immune Response
During the past two decades, nitric oxide (NO) has been recognized as one of the most versatile players in the immune system. It is involved in the pathogenesis and control of infectious diseases, tumors, autoimmune processes and chronic degenerative diseases. Read...
NO and Redox Mechanisms in the Immune Response
Renewed interest and appreciation. To regulate immune responses, these species trigger the eradication of pathogens on the one hand and modulate immunosuppression during tissue-restoration and wound-healing processes on the other. Read More