Blog
Blood Pressure Regulation in Stress Focus on NO
Stress is considered a risk factor associated with the development of various civilization diseases including cardiovascular diseases, malignant tumors and mental disorders. Research investigating mechanisms involved in stress-induced hypertension have attracted much...
NO Synthase Role in Sleep Homeostasis
The function of sleep remains one of the mysteries of the ages, yet sleep is an evolutionarily preserved behavior manifest in diverse organisms including worms (1), flies (2), and all vertebrates thus far examined (3). Perhaps one of the most compelling arguments for...
NO Inhibition Abolishes Sleep-Wake Differences
Nitric oxide inhibition abolishes sleep-wake differences in cerebral circulation. Am J Physiol Heart Circ Physiol 280: H2598–H2606, 2001.—Nitric oxide (NO), being produced by active neurones and also being a cerebral vasodilator, may couple brain activity and blood...
Synaptic Dysfunction in Depression
Basic and clinical studies demonstrate that depression is associated with reduced size of brain regions that regulate mood and cognition, including the prefrontal cortex and the hippocampus, and decreased neuronal synapses in these areas. Antidepressants can block or...
Role of NO in Muscle Regneration
We examined the role of nitric oxide (NO) in muscle repair and regeneration following repetitive eccentric contractions (ECC). A standardized exercise protocol was used to create eccentric contraction-induced injury to the left tibialis anterior muscle of 48 male...
NO Synthase Inhibition on Muscular Arteries During Exercise
We investigated acute effects of NO synthase inhibition on exercise hemodynamics using NG-monomethyl-l-arginine (l-NMMA), a nonselective NO synthase -inhibitor. Healthy volunteers (n=10, 5 female, 19–33 years) participated in a 2-phase randomized crossover study,...
Dietary NO Precursors and Exercise Performance
NO has received significant attention in exercise physiology and sports nutrition, with many NO “supplements” being sold as potential ergogenic aids. This is based on the important role of NO in many physiological processes related to exercise and recovery, including...
Contributions of Acetycholine and NO to Blood Flow
The contributions of acetylcholine and/or nitric oxide (NO) to the rapid changes in human forearm blood flow (FBF) at the onset and recovery from mild exercise were studied in eight subjects. Read More