NO Role in Pathogenesis of RA and Lupus

Nitric oxide (NO) has been shown to regulate T cellfunctions under physiological conditions, but overproduction of NO may contribute to T lymphocyte dysfunction. NO-dependent tissue injury has been implicated in a variety of rheumatic diseases, including systemic...

NO for Treating Rheumatoid Arthritis

Di-tert-butyl dicarbonate, 4-nitro-O-phenylenediamine, guanidine hydrochloride, sodium sulfate, palladium on carbon (PD/C), tetrahydrofuran, Celite® 545 AW, acryloyl chloride, trimethylamine, TFA, pyrrolidine, acetonitrile, sodium methoxide, N,N’-dimethylformamide,...

Reemergence of NO and Cancer

Nitric Oxide (NO), a lipophilic gas synthesise Ad by the enzyme Nitric Oxide Synthase (NOS) from the substrate arginine, is an important biomolecule that mediates cellular signaling. It has a wide spectrum of biological functions including immunomodulation,...

NO and the Immune Response

During the past two decades, nitric oxide (NO) has been recognized as one of the most versatile players in the immune system. It is involved in the pathogenesis and control of infectious diseases, tumors, autoimmune processes and chronic degenerative diseases. Read...